Tretinoin before and after aging12/14/2023 ![]() ![]() 5, 6 These changes are readily appreciated by inspecting the upper inner arm. In intrinsic, natural, or chronologic aging, skin loses its youthful appearance by becoming thinner, laxer, and more finely wrinkled. 3, 4 Human skin not exposed to the sun also ages but less dramatically. In this premature skin aging (ie, photoaging), matrix degradation triggered by solar radiation is critical in causing the wrinkled phenotype, 1, 2 and topical use of retinoids can offer clinical improvement. Wrinkles and brown spots that represent aged features are accentuated in the habitually sun-exposed face and the back of the hands. Trial Registration Identifier: NCT00272610 With greater skin matrix synthesis, retinol-treated aged skin is more likely to withstand skin injury and ulcer formation along with improved appearance. Significant induction of glycosaminoglycan, which is known to retain substantial water, and increased collagen production are most likely responsible for wrinkle effacement. As measured in a subgroup, retinol treatment significantly increased glycosaminoglycan expression ( P = .02 ) and procollagen I immunostaining ( P = .049 ) compared with vehicle.Ĭonclusions Topical retinol improves fine wrinkles associated with natural aging. Results After 24 weeks, an intent-to-treat analysis using the last-observation-carried-forward method revealed that there were significant differences between retinol-treated and vehicle-treated skin for changes in fine wrinkling scores (−1.64 vs −0.08 P<.001). Main Outcome Measures Clinical assessment using a semiquantitative scale (0, none 9, most severe) and biochemical measurements from skin biopsy specimens obtained from treated areas. ![]() Intervention Topical 0.4% retinol lotion or its vehicle was applied at each visit by study personnel to either the right or the left arm, up to 3 times a week for 24 weeks. Patients The study population comprised 36 elderly subjects (mean age, 87 years), residing in 2 senior citizen facilities. Objective To evaluate the effectiveness of topical retinol (vitamin A) in improving the clinical signs of naturally aged skin.ĭesign Randomized, double-blind, vehicle-controlled, left and right arm comparison study. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography. ![]()
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